KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MMP11
All Species:
22.42
Human Site:
T427
Identified Species:
54.81
UniProt:
P24347
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P24347
NP_005931.2
488
54618
T427
S
P
V
P
R
R
A
T
D
W
R
G
V
P
S
Chimpanzee
Pan troglodytes
XP_515022
469
52600
T408
S
P
V
P
R
R
A
T
D
W
R
G
V
P
S
Rhesus Macaque
Macaca mulatta
XP_001083910
488
54748
T427
S
P
V
P
R
R
A
T
D
W
R
G
V
P
S
Dog
Lupus familis
XP_543534
489
54823
T428
S
P
V
P
R
R
A
T
D
W
R
G
V
P
S
Cat
Felis silvestris
Mouse
Mus musculus
Q02853
492
55423
T431
N
P
V
P
R
R
S
T
D
W
R
G
V
P
S
Rat
Rattus norvegicus
Q499S5
491
55493
T430
N
P
V
P
R
R
T
T
D
W
R
G
V
P
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_001232777
502
56708
A441
N
V
Y
P
R
T
M
A
D
W
R
G
V
P
Q
Frog
Xenopus laevis
Q11005
477
54423
G413
S
R
H
S
R
R
I
G
D
W
R
G
V
P
K
Zebra Danio
Brachydanio rerio
XP_692205
483
55535
Q427
S
A
P
R
R
I
Q
Q
D
W
W
G
V
P
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780356
489
56331
E408
G
Y
P
K
L
I
K
E
N
W
L
G
V
P
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93
97.3
86.9
N.A.
81.7
81.6
N.A.
N.A.
64.3
61.4
56.3
N.A.
N.A.
N.A.
N.A.
39.8
Protein Similarity:
100
93.4
97.7
91.4
N.A.
87.4
86.7
N.A.
N.A.
73.9
73.9
67.4
N.A.
N.A.
N.A.
N.A.
53.1
P-Site Identity:
100
100
100
100
N.A.
86.6
86.6
N.A.
N.A.
53.3
60
46.6
N.A.
N.A.
N.A.
N.A.
26.6
P-Site Similarity:
100
100
100
100
N.A.
100
93.3
N.A.
N.A.
60
60
46.6
N.A.
N.A.
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
0
0
40
10
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
90
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
10
0
0
0
0
0
0
10
0
0
0
100
0
0
0
% G
% His:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
20
10
0
0
0
0
0
0
0
10
% I
% Lys:
0
0
0
10
0
0
10
0
0
0
0
0
0
0
10
% K
% Leu:
0
0
0
0
10
0
0
0
0
0
10
0
0
0
0
% L
% Met:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% M
% Asn:
30
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% N
% Pro:
0
60
20
70
0
0
0
0
0
0
0
0
0
100
0
% P
% Gln:
0
0
0
0
0
0
10
10
0
0
0
0
0
0
10
% Q
% Arg:
0
10
0
10
90
70
0
0
0
0
80
0
0
0
0
% R
% Ser:
60
0
0
10
0
0
10
0
0
0
0
0
0
0
60
% S
% Thr:
0
0
0
0
0
10
10
60
0
0
0
0
0
0
0
% T
% Val:
0
10
60
0
0
0
0
0
0
0
0
0
100
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
100
10
0
0
0
0
% W
% Tyr:
0
10
10
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _